The setup i've been using for my first 50 toon, should let you deal with anything Paleview can throw at you, assuming you never need to sneak.
Perk 1-30
Sprinter V
SMG Expert V
Marksman V
Reloading V
Head Hunter V
Hunter V
Perk 31-50
Lumberjack V
Jogger V
Looter V
Quick Shot V
Prestige
Quick Reflexes V
The dual mobility skills may be a controversial choice, but it lets me keep up with boss hunt parties despite my Leg gear prioritising IDR, Stun Recovery and Inventory Capacity over Sprint stats. Likewise I picked Looter primarily for the Search Speed so I can get the loot and move to the next boss as quickly as possible.
As I only use my Chainsaw against Infected, my Cut-Off Saw is a Stat Stick, with DVM, Inventory Capacity, and Sprint Stats. If I could get IDR on it as well I would in preparation for Comer and Sons runs. I swap out to a Body Damage / Attack Speed one for OA grinding.
- Anialator